Resumo Objetivo Esta meta-análise teve como objetivo avaliar a sensibilidade e especificidade da colonografia por tomografia computadorizada na detecção de pólipos colorretais. Métodos Foi realizada uma pesquisa bibliográfica nas bases de dados da PubMed e da Web of Science. Resultados Um total de 1.872 pacientes, 57,2% homens e 42,8% mulheres, com idades entre 49 a 82 anos de idade (média de 59,7 ± 5,3 anos) foram incluídos nesta meta análise. A sensibilidade da colonografia por tomografia computadorizada foi estimada em 88,4% (46,3-95,7%; coeficiente de variância [CV]=28,5%) e a especificidade em 73,6% (47,4%-100,0%; CV=37,5%). Para lesões de até 9mm, a sensibilidade foi de 82,5% (62,0-99,9%; CV=25,1%) e a especificidade de 79,2% (32,0-98,0%; CV=22,9%). Para lesõesmaiores que 9mm, a sensibilidade foi de 90,2% (64,0-100,0%; CV=7,4%) e a especificidade de 94,7% (80,0-100,0%; CV=6,2%). Não houve diferença estatisticamente significante entre as sensibilidades por tamanho da lesão (p=0,0958), porém a especificidade foi maior em lesões acima de 9mm (p<0,0001). Conclusão A maioria dos estudos analisados no presente trabalho foi realizada antes de 2010, cerca de uma década depois que a colonografia por tomografia computadorizada passou a ser indicada como método de triagem pelas diretrizes europeias e americanas. Portanto, são necessários mais estudos com o objetivo de analisar a técnica apósmaiores avanços tecnológicos, o que poderia levar ao desenvolvimento de dispositivos mais modernos.

Abstract Objective This metanalysis aimed to evaluate the sensitivity and specificity of computed tomography colonography in colorectal polyp detection. Methods A literature search was performed in the PubMed and Web of Science databases. Results A total of 1,872 patients (males 57.2%, females 42.8%) aged 49 to 82 years old (mean age 59.7 ± 5.3 years) were included in this metanalysis. The estimated sensitivity of computed tomography colonography was 88.4% (46.3-95.7%, coefficient of variation [CV]=28.5%) and the estimated specificity was 73.6% (47.4-100.0%, CV=37.5%). For lesions up to 9mm, the sensitivity was 82.5% (62.0-99.9%, CV =25.1%) and the specificity was 79.2% (32.0-98.0%, CV=22.9%). For lesions>9mm, the sensitivity was 90.2% (64.0-100.0%, CV=7.4%) and the specificity was 94.7% (80.0-100.0%, CV=6.2%). No statistically significant differences in sensitivity according to the size of the lesion were found (p=0.0958); however, the specificity was higher for lesions>9mm (p<0.0001). Conclusions Most of the studies analyzed in the present work were conducted before 2010, which is about a decade after computed tomography colonography started being indicated as a screening method by European and American guidelines. Therefore, more studies aimed at analyzing the technique after further technological advancements are necessary, which could lead to the development of more modern devices.

RESUMO Este artigo descreve a metodologia para a integração de predicados nominais, do tipo construções com verbo-suporte (CVS), no analisador sintático automático XIP, que é utilizado pela cadeia de processamento do Português STRING. Trata-se, mais especificamente, de 580 CVS com o verbo dar e um nome predicativo, cujas propriedades sintático-semânticas foram descritas, formalizadas e, em seguida, integradas à gramática do XIP, por meio de regras, a fim de extrair a dependência SUPPORT entre o nome predicativo (Npred) e o verbo-suporte (Vsup). A necessidade de tratar automaticamente as CVS decorre do fato de que elas são diferentes de construções com verbo pleno, possuem estruturas sintáticas complexas, possuem propriedades sintático-semânticas específicas e admitem transformações sintáticas sistemáticas, ainda que lexicalmente determinadas. O conceito de CVS, bem como a abordagem léxico-sintática adotada, segue os princípios teóricos e metodológicos do Léxico-Gramática. Como resultado da integração desses dados ao parser XIP, o sistema atingiu precisão de 85%, abrangência de 87%, acurácia de 80% e medida-F de 86%.

ABSTRACT This article describes the methodology for the integration of nominal predicates, that is, support verb constructions (SVC), in the XIP parser, which is used by STRING, a Portuguese processing chain. More specifically, 580 SVC with the support verb (Vsup) dar ‘give’ and a predicative noun (Npred), whose syntactic-semantic properties have been described, formalized and then integrated into the Portuguese grammar of XIP, by means of rules, in order to extract the syntactic dependency (noted SUPPORT) between the Npred and the Vsup. The need to automatically treat SVC derives from the fact that they are different from full-verb constructions, have complex syntactic structures, have specific syntactic-semantic properties, and allow several systematic, albeit lexically determined, syntactic transformations. The concept of SVC, as well as the lexical-syntactic approach here adopted, follows the theoretical and methodological principles of the Lexicon-Grammar theory. As a result of integrating these data into the XIP parser, the system achieved 85% precision, 87% recall, 80% accuracy and 86% F-measure on an evaluation corpus, specifically built for this purpose.

OBJECTIVE: This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as well as to establish a correlation between HPV type and cancer prognosis. METHODS: A single-center cohort study was conducted with 86 patients who had undergone radical hysterectomy for stage I cervical cancer. Prognostic factors and the presence of HPV 16 and 18 were analyzed using a polymerase chain reaction assay. A univariate analysis using Kaplan-Meier curves was conducted to estimate survival. RESULTS: The prevalence of HPV 16 in the study group was 65.3%, and the prevalence of HPV 18 was 33.3%. The prevalence of infection with both viruses was 26.9%. Overall survival at 5 years was 91% among women with HPV 18 and 96% among those without this virus type (p = 0.133). Among the women with HPV 16, the overall survival was 94%, whereas this rate was 96% among those without this virus type (p = 0.663). Disease-free survival was unaffected by the presence of HPV type 16 or 18. CONCLUSION: In the present study, despite the high prevalence of HPV types 16 and 18, the presence of these virus types did not affect the prognosis of patients with stage I cervical cancer who underwent radical hysterectomy.